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Taking on advisory and project work

Single-Cell Genomics Consultant

From challenging samples to polished results.

I guide teams on single-cell and nuclei sample prep, application development, and QC advisory and analysis.

With 20+ years of experience and 20+ peer reviewed publications, I can help your team successfully navigate end-to-end single-cell workflows.

Hands-on with10x GenomicsParse BiosciencesScale BiosciencesPIPseqMission Bio Tapestri

How I help

Three kinds of engagement. Most start with a short call to work out which one you actually need.

Single-cell Workflows

for biotech R&D teams

Sample Prep Guidance

For teams whose starting material fights back — solid tissue, FFPE, frozen, or precious low-input samples that won't yield clean cells or nuclei.

  • Tissue dissociation and nuclei extraction protocols
  • Troubleshooting viability and debris content
  • Go/no-go criteria before samples reach the instrument

Platform Selection and Method Development

For teams choosing between platforms, or who already have one on the bench and need a working assay built on it.

  • Vendor-neutral comparison for your sample type and question
  • Benchmarking runs and evaluation design
  • Assay development and hands-on team training

QC Strategy and Analysis

For teams with data in hand who need to know whether it's sound, and what it will take to make the result defensible.

  • QC metrics and acceptance criteria for your runs
  • Troubleshooting doublets, depth and data artifacts
  • Clustering and annotation review before conclusions land

Emerging Technologies

for platform and tools companies

Technology Landscape and Application Evaluation

For platform companies and investors deciding whether a new technology is real, where it fits, and which applications are worth building first.

  • Competitive benchmarking against established platforms
  • Application roadmap — which use cases to build first
  • Technical diligence on scientific claims

KOL and Customer Outreach

For platform companies who need a working scientist — not a sales engineer — in front of the labs whose adoption decides whether a technology lands.

  • KOL identification and relationship development
  • Scientific demos, seminars and workshops
  • Early-access and evaluation program design

Litigation Support

for attorneys and legal teams

Expert Witness Testimony

Data interpretation and lay translation.

  • Biochemistry
  • Genomics
  • Genetics

How I work

  1. 01

    Start with the decision

    Most engagements begin because a decision is stuck — which platform, whether the data is trustworthy, why the samples keep failing. I want to understand the decision before I look at the protocol.

  2. 02

    Work at the bench level

    I have run these platforms myself, on difficult samples, at scale. Recommendations come with the protocol detail needed to act on them, not a summary slide.

  3. 03

    Leave the team able to repeat it

    I have spent years training customers on instruments in their own labs. The goal is that your team can run it again after I am gone, without me.

About

I help research teams and platform companies turn difficult samples into single-cell data and collateral to grow their businesses.

I have spent twenty years on the technical side of genomics and oncology research. I trained in academic labs on transcription and epigenetics in model systems and human disease. At the National Cancer Institute I led a functional genomics core working on rare variants in cancer. At Levitas Bio, I led development of an automated sample preparation platform and built the methods behind single-cell and single-nuclei workflows helping to drive over 80% of company revenue.

I can help you:

  • Onboard new technology
  • Troubleshoot sample prep issues
  • Validate data integrity
Full CV, publications and talks →
Seth A. Brodie, Ph.D.

Get in touch

Tell me what you are working on and where it is stuck. If I am not the right person, I will usually know who is.

Taking on advisory and project work